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*                        theophylline_project.mlxtran                          *
*                        February 06, 2018 at 14:58:40                         *
*                        Monolix version : 5.0.0                               *
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POPULATION PARAMETERS ESTIMATION _______________________________________________

Fixed Effects ----------------------------     se_sa    rse(%)    pvalue    se_lin    rse(%)    pvalue
ka_pop                         :      1.55     0.289      18.6               0.289      18.7          
V_pop                          :      32.2      1.55       4.8                1.55      4.81          
Cl_pop                         :      2.83     0.227      8.04               0.227      8.03          
beta_Cl_lw70                   :     0.739     0.606      82.1     0.223     0.599      81.1     0.218

Standard Deviation of the Random Effects -
omega_ka                       :     0.608     0.146      23.9               0.138      22.6          
omega_V                        :     0.138      0.04      28.9              0.0396      28.6          
omega_Cl                       :     0.252    0.0627      24.9               0.061      24.2          

Error Model Parameters -------------------
a                              :     0.595     0.123      20.6               0.104      17.5          
b                              :    0.0765    0.0319      41.8              0.0253        33          

Elapsed time (seconds) :      5.8
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CORRELATION MATRIX OF THE ESTIMATES ____________________________________________

Fisher by Linearization --------------------------------------------------------
Correlation Matrix :
      ka_pop   1.00000
       V_pop   0.13741   1.00000
      Cl_pop  -0.05651  -0.11798   1.00000
beta_Cl_lw70  -0.00123   0.00350   0.11756   1.00000
    omega_ka   0.00000   0.00000   0.00000   0.00000   1.00000
     omega_V   0.00000   0.00000   0.00000   0.00000  -0.01510   1.00000
    omega_Cl   0.00000   0.00000   0.00000   0.00000   0.00011  -0.01004   1.00000
           a   0.00000   0.00000   0.00000   0.00000  -0.01379  -0.00947  -0.06827   1.00000
           b   0.00000   0.00000   0.00000   0.00000  -0.00554  -0.05526   0.03659  -0.77188   1.00000
                               min       max   max/min
Eigen values           :      0.22       1.8       7.9

Elapsed time (seconds) :   0.002
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Fisher by Stochastic Approximation ---------------------------------------------
Correlation Matrix :
      ka_pop   1.00000
       V_pop   0.12499   1.00000
      Cl_pop  -0.05459  -0.11829   1.00000
beta_Cl_lw70  -0.00073  -0.00470   0.12272   1.00000
    omega_ka   0.03885  -0.02625   0.00353  -0.03353   1.00000
     omega_V   0.03607   0.02313  -0.03442  -0.10894   0.10980   1.00000
    omega_Cl  -0.01536  -0.02186   0.01948   0.02753  -0.01487  -0.15699   1.00000
           a   0.07979  -0.01138  -0.00957   0.07879  -0.00763   0.04391  -0.01118   1.00000
           b  -0.08599   0.03634   0.00999  -0.05347  -0.04531  -0.11188   0.00597  -0.83897   1.00000
                               min       max   max/min
Eigen values           :      0.16       1.9        12

Elapsed time (seconds) :    0.51
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INDIVIDUAL PARAMETERS ESTIMATION _______________________________________________

Individual Parameters Estimation by Conditional Mean ---------------------------
           min        Q1    median        Q3       max
ka :     0.743      1.01      1.45      2.12      5.98
V  :      26.6      28.7      32.9      36.1      38.5
Cl :      1.73      2.37      3.02      3.35      4.07

Elapsed time (seconds) :       1
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Individual Parameters Estimation by Conditional Mode ---------------------------
           min        Q1    median        Q3       max
ka :     0.731     0.987      1.41      2.07      5.46
V  :      26.6      28.5      32.7      35.8      38.4
Cl :      1.74      2.38      3.02      3.36      4.06

Elapsed time (seconds) :   0.006
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LOG-LIKELIHOOD ESTIMATION ______________________________________________________
                                               (lin)           (is)

-2 x log-likelihood                 :         342.21         344.14
Akaike Information Criteria   (AIC) :         360.21         362.14
Bayesian Information Criteria (BIC) :         364.58         366.51

Elapsed time              (seconds) :          0.001           0.87


[Importance Sampling] Standard error        : 0.0209
                      Sampling distribution : T-distribution with 5 degrees of freedom
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